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Other Antibiotics Several other antibiotics are being studied in the treatment of CDAD. Musher and associates published a prospective double-blinded study in 2006 comparing metronidazole and nitazoxanide as initial therapy and concluded that nitazoxanide was as effective as metronidazole. 25 Of note, this initial study excluded ICU patients and those with hemodynamic instability, IBD, advanced liver disease, or renal disease.
The same group of researchers recently published an open-label study of nitazoxanide in patients who had failed metronidazole therapy.