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In details, the C max and AUC 0-t values of infected mice were lower than that of uninfected mice with prolonged T max. However, the mechanism would be clarified by further study on this topic. These results suggested that the absorption rate which is relevant to the value of T max, still limit the absorption of MBZ into the plasma.
After oral administration of MBZ-OS, the drug concentrations in lung, spleen kidney, heart and brain were higher than that of the MBZ-1 tragacanth.
However, contributed by the accumulated indissolvable parent drug, the C max value of MBZ-1 tragacanth was nearly 6 times of the new formulation in the intestine.