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Eukaryotes have been documented doing insane things with their genomes like making extrachromosomal copies of their genes. For example, a frog egg contains thousands of little plasmid-like elements containing ribosomal DNA. It turns out that plants and animals have lots of extrachromosomal DNAs, and some eukaryotes have cyclical polyploidization where they can be haploid, diploid, thousand-ploid, and then return to diploid during their life cycles.

Initially these genome features were dismissed as freakish and weird, but in our hands, when we do the analyses, things like cyclical ploidization and developmentally-regulated genome rearrangements turn out to be more widespread than previously thought. We argued, therefore, that the last common ancestor (LCA) of eukaryotes may have had a dynamic genome which could alter its ploidy cycles and rearrange its chromosomes in some developmentally-regulated way.