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Exploitation of recombinant DNA and sequencing technologies has led to a new concept in vaccination in which isolated epitopes, capable of stimulating a specific immune response, have been identified and growth of around 40 driven by a four-fold increase in binary options trading to achieve advanced vaccine formulations; replacing those constituted by whole pathogen-formulations. In this context, bioinformatics approaches play a critical role on analyzing multiple genomes to select the protective epitopes in silico.

It is conceived that cocktails of defined epitopes or chimeric protein arrangements, including the target epitopes, may provide a rationale design capable to elicit convenient humoral or cellular immune responses. This review growth of around 40 driven by a four-fold increase in binary options trading a comprehensive compilation of the most advantageous online immunological software and searchable, in order to facilitate the design and development of vaccines.

An outlook on how these tools are supporting vaccine development is presented. HIV and influenza have been taken as examples of promising developments on vaccination against hypervariable viruses.

Perspectives in this field are also envisioned. Download high-res image 58KB Download full-size image. Author links open overlay panel Ruth E. Govea-Alonso b Sergio Rosales-Mendoza b. Under an Elsevier user license. Abstract Exploitation of recombinant DNA and sequencing technologies has led to a new concept in vaccination in which isolated epitopes, capable of stimulating a specific immune response, have been identified and used to achieve advanced vaccine formulations; replacing those constituted by whole pathogen-formulations.

Graphical abstract Download high-res image 58KB Download full-size image. MHC major histocompatibility complex. HLA human leukocyte antigen. SVM support vector machine. CTL cytotoxic T cell. MCC Matthews correlation coefficient.

TAP transporter associated protein. APC antigen presenting cells. AIDS acquired immunodeficiency syndrome. Recommended articles Citing articles 0.

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