Journal of Special Operations Medicine - Article Index

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A series of novel 4-aminoquinoline—pyrimidine hybrids was synthesized and evaluated for their antimalarial activity. Several compounds showed potent antimalarial activity against both CQ -sensitive and CQ -resistant strains of P. The selected compound 7f , when evaluated for in vivo activity showed mild suppression of parasites in the P.

The heme binding studies were conducted to determine the probable mode of action of these hybrids. Compound 8d formed a stable 1: The top scoring compounds with low binding energy, interact in the active site of Pf-DHFR-TS in a similar way to the natural protein substrate dihydrofolate.

The pharmacokinetic properties of the most active compounds were also assessed using ADMET prediction. The article was received on 04 Sep , accepted on 10 Nov and first published on 14 Nov If you are not the author of this article and you wish to reproduce material from it in a third party non-RSC publication you must formally request permission using RightsLink.

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Information about reproducing material from RSC articles with different licences is available on our Permission Requests page. Fetching data from CrossRef. This may take some time to load. Jump to main content. Jump to site search. Previous Article Next Article. Synthesis, antimalarial activity, heme binding and docking studies of 4-aminoquinoline—pyrimidine based molecular hybrids. Back to tab navigation Download options Please wait Supplementary information PDF K.

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